Specific antibody binding to the APP(672–699) region shifts APP processing from α- to β-cleavage

Alzheimer's disease (AD), a progressive neurodegenerative disorder that is the most common cause of dementia in the elderly, is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles, as well as a progressive loss of synapses and neurons in the brain. The major...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Li, S, Deng, J, Hou, H, Tian, J, Giunta, B, Wang, Y, Sawmiller, D, Smith, A, Sanberg, P R, Obregon, D, Mori, T, Tan, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454311/
https://ncbi.nlm.nih.gov/pubmed/25118934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.336
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