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Specific antibody binding to the APP(672–699) region shifts APP processing from α- to β-cleavage
Alzheimer's disease (AD), a progressive neurodegenerative disorder that is the most common cause of dementia in the elderly, is characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles, as well as a progressive loss of synapses and neurons in the brain. The major...
Zapisane w:
| Wydane w: | Cell Death Dis |
|---|---|
| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4454311/ https://ncbi.nlm.nih.gov/pubmed/25118934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.336 |
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