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Rational design of allosteric-inhibition sites in classical protein tyrosine phosphatases
Protein tyrosine phosphatases (PTPs), which catalyze the dephosphorylation of phosphotyrosine in protein substrates, are critical regulators of metazoan cell signaling and have emerged as potential drug targets for a range of human diseases. Strategies for chemically targeting the function of indivi...
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| Publicado en: | Bioorg Med Chem |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4451255/ https://ncbi.nlm.nih.gov/pubmed/25828055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.027 |
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