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The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric...

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Hlavní autoři: Li, Shuai, Zhang, Jingmiao, Lu, Shaoyong, Huang, Wenkang, Geng, Lv, Shen, Qiancheng, Zhang, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022711/
https://ncbi.nlm.nih.gov/pubmed/24831294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097668
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