Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

The PTEN-induced putative kinase protein 1 (PINK1) and ubiquitin (UB) ligase PARKIN direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the mitochondrial outer membrane (MOM) for ubiquitylation of MOM proteins with canonical and noncanonical UB chains. PINK1 phosphorylate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ordureau, Alban, Heo, Jin-Mi, Duda, David M., Paulo, Joao A., Olszewski, Jennifer L., Yanishevski, David, Rinehart, Jesse, Schulman, Brenda A., Harper, J. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450373/
https://ncbi.nlm.nih.gov/pubmed/25969509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506593112
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