PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. However, it has been unclear how PINK1 activates and recruits Parkin to mitochondria. Although PINK1 phosphorylates Parkin, other PINK1 substrates appear to activate Parkin, as the mutation o...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kane, Lesley A., Lazarou, Michael, Fogel, Adam I., Li, Yan, Yamano, Koji, Sarraf, Shireen A., Banerjee, Soojay, Youle, Richard J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2014
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003245/
https://ncbi.nlm.nih.gov/pubmed/24751536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201402104
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन