PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. However, it has been unclear how PINK1 activates and recruits Parkin to mitochondria. Although PINK1 phosphorylates Parkin, other PINK1 substrates appear to activate Parkin, as the mutation o...

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Autori principali: Kane, Lesley A., Lazarou, Michael, Fogel, Adam I., Li, Yan, Yamano, Koji, Sarraf, Shireen A., Banerjee, Soojay, Youle, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003245/
https://ncbi.nlm.nih.gov/pubmed/24751536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201402104
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