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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. However, it has been unclear how PINK1 activates and recruits Parkin to mitochondria. Although PINK1 phosphorylates Parkin, other PINK1 substrates appear to activate Parkin, as the mutation o...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4003245/ https://ncbi.nlm.nih.gov/pubmed/24751536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201402104 |
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