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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

Genetic studies indicate that the mitochondrial kinase PINK1 and the RING-between-RING E3 ubiquitin ligase Parkin function in the same pathway. In concurrence, mechanistic studies show that PINK1 can recruit Parkin from the cytosol to the mitochondria, increase the ubiquitination activity of Parkin,...

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Autores principales: Lazarou, Michael, Narendra, Derek P., Jin, Seok Min, Tekle, Ephrem, Banerjee, Soojay, Youle, Richard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549971/
https://ncbi.nlm.nih.gov/pubmed/23319602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210111
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