PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

Genetic studies indicate that the mitochondrial kinase PINK1 and the RING-between-RING E3 ubiquitin ligase Parkin function in the same pathway. In concurrence, mechanistic studies show that PINK1 can recruit Parkin from the cytosol to the mitochondria, increase the ubiquitination activity of Parkin,...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Lazarou, Michael, Narendra, Derek P., Jin, Seok Min, Tekle, Ephrem, Banerjee, Soojay, Youle, Richard J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2013
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549971/
https://ncbi.nlm.nih.gov/pubmed/23319602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210111
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller