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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
Genetic studies indicate that the mitochondrial kinase PINK1 and the RING-between-RING E3 ubiquitin ligase Parkin function in the same pathway. In concurrence, mechanistic studies show that PINK1 can recruit Parkin from the cytosol to the mitochondria, increase the ubiquitination activity of Parkin,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549971/ https://ncbi.nlm.nih.gov/pubmed/23319602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210111 |
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