A cellular system that degrades misfolded proteins and protects against neurodegeneration

The accumulation of misfolded proteins compromises cellular function and causes debilitating diseases. However, the cellular systems that detect and degrade these proteins remain poorly understood. Here we show that the tripartite motif protein PML/TRIM19 and the SUMO-dependent ubiquitin ligase RNF4...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell
Hoofdauteurs: Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445634/
https://ncbi.nlm.nih.gov/pubmed/24882209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.030
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