Lataa...
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy
No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins by the ubiquitin-proteasome system (UPS) is vital to the cell. Proteasome impairment contributes to HF. Activation o...
Tallennettuna:
| Julkaisussa: | Sci Adv |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Association for the Advancement of Science
2019
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6531002/ https://ncbi.nlm.nih.gov/pubmed/31131329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw5870 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|