PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins by the ubiquitin-proteasome system (UPS) is vital to the cell. Proteasome impairment contributes to HF. Activation o...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Zhang, Hanming, Pan, Bo, Wu, Penglong, Parajuli, Nirmal, Rekhter, Mark D., Goldberg, Alfred L., Wang, Xuejun
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531002/
https://ncbi.nlm.nih.gov/pubmed/31131329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw5870
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker