PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins by the ubiquitin-proteasome system (UPS) is vital to the cell. Proteasome impairment contributes to HF. Activation o...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Zhang, Hanming, Pan, Bo, Wu, Penglong, Parajuli, Nirmal, Rekhter, Mark D., Goldberg, Alfred L., Wang, Xuejun
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2019
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531002/
https://ncbi.nlm.nih.gov/pubmed/31131329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw5870
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