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Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice
The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies, such as desmin-related cardiomyopathy, and implicated in many common diseases, including dilated cardiomyopathy and isch...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163952/ https://ncbi.nlm.nih.gov/pubmed/21841311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45709 |
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