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Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies, such as desmin-related cardiomyopathy, and implicated in many common diseases, including dilated cardiomyopathy and isch...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Jie, Horak, Kathleen M., Su, Huabo, Sanbe, Atsushi, Robbins, Jeffrey, Wang, Xuejun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163952/
https://ncbi.nlm.nih.gov/pubmed/21841311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45709
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