A cellular system that degrades misfolded proteins and protects against neurodegeneration

The accumulation of misfolded proteins compromises cellular function and causes debilitating diseases. However, the cellular systems that detect and degrade these proteins remain poorly understood. Here we show that the tripartite motif protein PML/TRIM19 and the SUMO-dependent ubiquitin ligase RNF4...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445634/
https://ncbi.nlm.nih.gov/pubmed/24882209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.030
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