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A cellular system that degrades misfolded proteins and protects against neurodegeneration
The accumulation of misfolded proteins compromises cellular function and causes debilitating diseases. However, the cellular systems that detect and degrade these proteins remain poorly understood. Here we show that the tripartite motif protein PML/TRIM19 and the SUMO-dependent ubiquitin ligase RNF4...
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| Veröffentlicht in: | Mol Cell |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4445634/ https://ncbi.nlm.nih.gov/pubmed/24882209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.030 |
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