A cellular system that degrades misfolded proteins and protects against neurodegeneration

The accumulation of misfolded proteins compromises cellular function and causes debilitating diseases. However, the cellular systems that detect and degrade these proteins remain poorly understood. Here we show that the tripartite motif protein PML/TRIM19 and the SUMO-dependent ubiquitin ligase RNF4...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445634/
https://ncbi.nlm.nih.gov/pubmed/24882209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.030
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