A cellular system that degrades misfolded proteins and protects against neurodegeneration

The accumulation of misfolded proteins compromises cellular function and causes debilitating diseases. However, the cellular systems that detect and degrade these proteins remain poorly understood. Here we show that the tripartite motif protein PML/TRIM19 and the SUMO-dependent ubiquitin ligase RNF4...

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Publicado en:Mol Cell
Autores principales: Guo, Lili, Giasson, Benoit I., Glavis-Bloom, Alex, Brewer, Michael D., Shorter, James, Gitler, Aaron D., Yang, Xiaolu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445634/
https://ncbi.nlm.nih.gov/pubmed/24882209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.030
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