Inhibitor of Apoptosis Signal-Regulating Kinase 1 Protects Against Acetaminophen-induced Liver Injury

Metabolic activation and oxidant stress are key events in the pathophysiology of acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by protein adduct formation is amplified by c-jun-N-terminal kinase (JNK), resulting in mitochondrial dysfunction and ultimately...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Xie, Yuchao, Ramachandran, Anup, Breckenridge, David G., Liles, John T., Lebofsky, Margitta, Farhood, Anwar, Jaeschke, Hartmut
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444402/
https://ncbi.nlm.nih.gov/pubmed/25818599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.03.019
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