Manganoporphyrins and Ascorbate Enhance Gemcitabine Cytotoxicity in Pancreatic Cancer

Pharmacological ascorbate (AscH(−)) selectively induces cytotoxicity in pancreatic cancer cells vs. normal cells via the generation of extracellular hydrogen peroxide (H(2)O(2)), producing double-stranded DNA breaks and ultimately cell death. Catalytic manganoporphyrins (MnPs) can enhance ascorbate-...

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Publicado en:Free Radic Biol Med
Main Authors: Cieslak, John A., Strother, Robert K., Rawal, Malvika, Du, Juan, Doskey, Claire M., Schroeder, Samuel R., Button, Anna, Wagner, Brett A., Buettner, Garry R., Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441864/
https://ncbi.nlm.nih.gov/pubmed/25725418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.02.018
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