Evaluation of [(18)F]-(−)-Norchlorofluorohomoepibatidine ([(18)F]-(−)-NCFHEB) as a PET Radioligand to Image the Nicotinic Acetylcholine Receptors in Non-human Primates

INTRODUCTION: The aims of the present study were to develop an optimized microfluidic method for the production of the selective nicotinic acetylcholine α(4)β(2) receptor radiotracer [(18)F]-(−)-NCFHEB ([(18)F]-Flubatine) and to investigate its receptor binding profile and pharmacokinetic properties...

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Publicado no:Nucl Med Biol
Main Authors: Bois, Frederic, Gallezot, Jean-Dominique, Zheng, Ming-Qiang, Lin, Shu-Fei, Esterlis, Irina, Cosgrove, Kelly P., Carson, Richard E., Huang, Yiyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441617/
https://ncbi.nlm.nih.gov/pubmed/25858513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.08.003
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