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Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand (18)F-(−)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys

OBJECTIVE: (18)F-(−)-NCFHEB (also known as (18)F-(−)-Flubatine) is a new radioligand to image α4β2* nicotinic acetylcholine receptors in vivo with positron emission tomography (PET), with faster kinetics than previous radioligands such as (18)F-2-F-A85380. The goal of this study was to assess the se...

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Detalhes bibliográficos
Publicado no:Synapse
Main Authors: Gallezot, Jean-Dominique, Esterlis, Irina, Bois, Frederic, Zheng, Ming-Qiang, Lin, Shu-fei, Kloczynski, Tracy, Krystal, John H., Huang, Yiyun, Sabri, Osama, Carson, Richard E., Cosgrove, Kelly P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224280/
https://ncbi.nlm.nih.gov/pubmed/25043426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.21767
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