Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA

Trifluridine (FTD) and 2′-deoxy-5-fluorouridine (FdUrd), a derivative of 5-fluorouracil (5-FU), are antitumor agents that inhibit thymidylate synthase activity and their nucleotides are incorporated into DNA. However, it is evident that several differences occur in the underlying antitumor mechanism...

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Gepubliceerd in:Int J Oncol
Hoofdauteurs: SAKAMOTO, KAZUKI, YOKOGAWA, TATSUSHI, UENO, HIROYUKI, OGUCHI, KEI, KAZUNO, HIROMI, ISHIDA, KEIJI, TANAKA, NOZOMU, OSADA, AKIKO, YAMADA, YUKARI, OKABE, HIROYUKI, MATSUO, KENICHI
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441292/
https://ncbi.nlm.nih.gov/pubmed/25901475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.2974
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