Interferon-α Enhances 5′-Deoxy-5-Fluorouridine-Induced Apoptosis by ERK-Dependant Upregulation of Thymidine Phosphorylase

5-Florouracil (5-FU) is the basic agent used in the treatment of gastric cancer. Capecitabine, a prodrug of 5-FU, displays increased antitumor efficacy compared with 5-FU in the clinic. 5′-Deoxy-5-fluorouracil (5′-DFUR), the metabolite of capecitabine, is converted to 5-FU by the enzyme thymidine ph...

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Detalhes bibliográficos
Main Authors: Zhu, Yike, Xu, Ling, Fan, Yibo, Li, Ce, Zhang, Ye, Zheng, Huachuan, Hou, Kezuo, Qu, Xiujuan, Liu, Yunpeng
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762072/
https://ncbi.nlm.nih.gov/pubmed/24027750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/132793
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