Increased cytotoxicity and bystander effect of 5-fluorouracil and 5′-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase

5-Fluorouracil (5-FU) and 5′-deoxy-5-fluorouridine (5′-DFUR), a prodrug of 5-FU, are anticancer agents activated by thymidine phosphorylase (TP). Transfecting the human TP cDNA into cancer cells in order to sensitize them to these pyrimidine antimetabolites may be an important approach in human canc...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Evrard, A, Cuq, P, Ciccolini, J, Vian, L, Cano, J-P
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1999
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363120/
https://ncbi.nlm.nih.gov/pubmed/10468288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690589
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