Enhancement of the Anti‐tumor Effect of 5′‐Deoxy‐5‐fluorouridine by Transfection of Thymidine Phosphorylase Gene into Human Colon Cancer Cells

Thymidine phosphorylase (dThdPase) is an enzyme that converts 5′‐deoxy‐5‐fluorouridine (5′DFUR) to the toxic substance 5‐fluorouracil (5‐FU); it is also known to be a platelet‐derived endothelial cell growth factor. In order to investigate the feasibility of suicide gene therapy against colorectal c...

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Détails bibliographiques
Publié dans:Jpn J Cancer Res
Auteurs principaux: Kanyama, Hiroki, Tomita, Naohiro, Yamano, Tomoki, Miyoshi, Yasuo, Ohue, Masayuki, Fujiwara, Yoshiyuki, Sekimoto, Mitsugu, Sakita, Isao, Tamaki, Yasuhiro, Monden, Morito
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 1999
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926090/
https://ncbi.nlm.nih.gov/pubmed/10363585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1999.tb00769.x
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