Enhancement of the Anti‐tumor Effect of 5′‐Deoxy‐5‐fluorouridine by Transfection of Thymidine Phosphorylase Gene into Human Colon Cancer Cells

Thymidine phosphorylase (dThdPase) is an enzyme that converts 5′‐deoxy‐5‐fluorouridine (5′DFUR) to the toxic substance 5‐fluorouracil (5‐FU); it is also known to be a platelet‐derived endothelial cell growth factor. In order to investigate the feasibility of suicide gene therapy against colorectal c...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kanyama, Hiroki, Tomita, Naohiro, Yamano, Tomoki, Miyoshi, Yasuo, Ohue, Masayuki, Fujiwara, Yoshiyuki, Sekimoto, Mitsugu, Sakita, Isao, Tamaki, Yasuhiro, Monden, Morito
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926090/
https://ncbi.nlm.nih.gov/pubmed/10363585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1999.tb00769.x
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