Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level

Trifluridine (FTD), a tri-fluorinated thymidine analogue, is a key component of the oral antitumor drug FTD/TPI (also known as TAS-102), which is used to treat refractory metastatic colorectal cancer. Thymidine kinase 1 (TK1) is thought to be important for the incorporation of FTD into DNA, resultin...

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Pubblicato in:Sci Rep
Autori principali: Kataoka, Yuki, Iimori, Makoto, Niimi, Shinichiro, Tsukihara, Hiroshi, Wakasa, Takeshi, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko, Kitao, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538667/
https://ncbi.nlm.nih.gov/pubmed/31138881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44399-6
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