Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Trifluridine/tipiracil (TFTD, TAS-102) is an orally administrated anti-cancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC). Trifluridine (FTD) is an active cytotoxic component of TFTD and mediates the anticancer effect via its incorporation into DNA. However, it...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nakanishi, Ryota, Kitao, Hiroyuki, Kiniwa, Mamoru, Morodomi, Yosuke, Iimori, Makoto, Kurashige, Junji, Sugiyama, Masahiko, Nakashima, Yuichiro, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717244/
https://ncbi.nlm.nih.gov/pubmed/29208954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17282-5
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