Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Trifluridine/tipiracil (TFTD, TAS-102) is an orally administrated anti-cancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC). Trifluridine (FTD) is an active cytotoxic component of TFTD and mediates the anticancer effect via its incorporation into DNA. However, it...

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Vydáno v:Sci Rep
Hlavní autoři: Nakanishi, Ryota, Kitao, Hiroyuki, Kiniwa, Mamoru, Morodomi, Yosuke, Iimori, Makoto, Kurashige, Junji, Sugiyama, Masahiko, Nakashima, Yuichiro, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717244/
https://ncbi.nlm.nih.gov/pubmed/29208954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17282-5
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