The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Trifluridine (FTD) is a key component of the novel oral antitumor drug TAS-102 (also named TFTD), which consists of FTD and a thymidine phosphorylase inhibitor. FTD is supposed to exert its cytotoxicity via massive misincorporation into DNA, but the underlying mechanism of FTD incorporation into DNA...

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Vydáno v:Sci Rep
Hlavní autoři: Kitao, Hiroyuki, Morodomi, Yosuke, Niimi, Shinichiro, Kiniwa, Mamoru, Shigeno, Kazuhiko, Matsuoka, Kazuaki, Kataoka, Yuki, Iimori, Makoto, Tokunaga, Eriko, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853717/
https://ncbi.nlm.nih.gov/pubmed/27137226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25286
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