Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

TAS-102 is a novel oral nucleoside antitumor agent containing trifluridine (FTD) and tipiracil hydrochloride (TPI). The compound improves overall survival of colorectal cancer (CRC) patients who are insensitive to standard chemotherapies. FTD possesses direct antitumor activity since it inhibits thy...

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Publicat a:Oncol Rep
Autors principals: TANAKA, NOZOMU, SAKAMOTO, KAZUKI, OKABE, HIROYUKI, FUJIOKA, AKIO, YAMAMURA, KEISUKE, NAKAGAWA, FUMIO, NAGASE, HIDEKI, YOKOGAWA, TATSUSHI, OGUCHI, KEI, ISHIDA, KEIJI, OSADA, AKIKO, KAZUNO, HIROMI, YAMADA, YUKARI, MATSUO, KENICHI
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240496/
https://ncbi.nlm.nih.gov/pubmed/25230742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2014.3487
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