NHEJ Often Uses Microhomology: Implications for Alternative End Joining

Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in NHEJ and responsible for most nucleolytic end processing in NHEJ. About 60% of NHEJ events show an alignment of the DNA ends that uses 1 or 2 bp of microhomology (MH) between the two DNA termini. Thus, MH is a c...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Pannunzio, Nicholas R., Li, Sicong, Watanabe, Go, Lieber, Michael R.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440676/
https://ncbi.nlm.nih.gov/pubmed/24613510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.02.006
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