Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation

Although ceramide accumulation in the heart is considered a major factor in promoting apoptosis and cardiac disorders, including heart failure, lipotoxicity and ischemia-reperfusion injury, little is known about ceramide’s role in mediating changes in contractility. In the present study, we measured...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Simon, Jillian N., Chowdhury, Shamim A.K., Warren, Chad M., Sadayappan, Sakthivel, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440670/
https://ncbi.nlm.nih.gov/pubmed/25280528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-014-0445-6
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