An Important Role of CDK Inhibitor p18(INK4c) in Modulating Antigen Receptor-Mediated T Cell Proliferation

The inhibitors of cyclin-dependent kinase (CDK) 4 (INK4) bind CDK4/6 to prevent their association with D-cyclins and G(1) cell cycle initiation and progression. We report here that among the seven CDK inhibitors, p18(INK4c) played an important role in modulating TCR-mediated T cell proliferation. Lo...

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Udgivet i:J Immunol
Main Authors: Kovalev, Grigoriy I., Franklin, David S., Coffield, V. McNeil, Xiong, Yue, Su, Lishan
Format: Artigo
Sprog:Inglês
Udgivet: 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435948/
https://ncbi.nlm.nih.gov/pubmed/11544316
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