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Genetic Evidence for Functional Dependency of p18(Ink4c) on Cdk4
The INK4 family of cyclin-dependent kinase (CDK) inhibitors negatively regulates cyclin D-dependent CDK4 and CDK6 and induces the growth-suppressive function of Rb family proteins. Mutations in the Cdk4 gene conferring INK4 resistance are associated with familial and sporadic melanoma in humans and...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC444851/ https://ncbi.nlm.nih.gov/pubmed/15254233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6653-6664.2004 |
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