CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis

Mammary epithelia are composed of luminal and myoepithelial/basal cells whose neoplastic transformations lead to distinct types of breast cancers with diverse clinical features. We report that mice deficient for the CDK4/6 inhibitor p18(Ink4c) spontaneously develop ER-positive luminal tumors at a hi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pei, Xin-Hai, Bai, Feng, Smith, Matthew D., Usary, Jerry, Fan, Cheng, Pai, Sung-Yun, Ho, I-Cheng, Perou, Charles M., Xiong, Yue
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699569/
https://ncbi.nlm.nih.gov/pubmed/19411068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.03.004
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg