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p16(INK4a) suppresses BRCA1-deficient mammary tumorigenesis
Senescence prevents the proliferation of genomically damaged, but otherwise replication competent cells at risk of neoplastic transformation. p16(INK4A) (p16), an inhibitor of CDK4 and CDK6, plays a critical role in controlling cellular senescence in multiple organs. Functional inactivation of p16 b...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5356676/ https://ncbi.nlm.nih.gov/pubmed/27811360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13015 |
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