p16(INK4a) suppresses BRCA1-deficient mammary tumorigenesis

Senescence prevents the proliferation of genomically damaged, but otherwise replication competent cells at risk of neoplastic transformation. p16(INK4A) (p16), an inhibitor of CDK4 and CDK6, plays a critical role in controlling cellular senescence in multiple organs. Functional inactivation of p16 b...

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Udgivet i:Oncotarget
Main Authors: Scott, Alexandria, Bai, Feng, Chan, Ho Lam, Liu, Shiqin, Ma, Jinshan, Slingerland, Joyce M, Robbins, David J., Capobianco, Anthony J., Pei, Xin-Hai
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356676/
https://ncbi.nlm.nih.gov/pubmed/27811360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13015
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