Development of an HTS Compatible Assay for Discovery of RORα Modulators using AlphaScreen® Technology

The retinoid acid receptor-related orphan receptors (RORs) represent important targets for treatment of metabolic and immune disorders. Here we describe the application of AlphaScreen® technology to develop an HTS compatible assay to facilitate the discovery of RORα modulators. Using the ligand bind...

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Publicat a:J Biomol Screen
Autors principals: Istrate, Monica A., Spicer, Timothy P., Wang, Yan, Bernard, Jerrold A., Helvering, Leah M., Bocchinfuso, Wayne P., Richardson, Timothy I., Zink, Richard, Kumar, Naresh, Montrose-Rafizadeh, Chahrzad, Dodge, Jeffrey, Hodder, Peter, Griffin, Patrick R.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434603/
https://ncbi.nlm.nih.gov/pubmed/21297105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110389040
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