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Development of HTS Assays and Pilot Screen for Inhibitors of Metalloproteases Meprin α and β

Zinc metalloproteinases meprin α and meprin β are implicated in a variety of diseases, such as fibrosis, inflammation and neurodegeneration, however, there are no selective small molecule inhibitors that would allow to study their role in these processes. To address this lack of molecular tools we h...

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Bibliographische Detailangaben
Veröffentlicht in:Biopolymers
Hauptverfasser: Madoux, Franck, Tredup, Claudia, Spicer, Timothy P., Scampavia, Louis, Chase, Peter S., Hodder, Peter S., Fields, Gregg B., Becker-Pauly, Christoph, Minond, Dmitriy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339026/
https://ncbi.nlm.nih.gov/pubmed/25048711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22527
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