CD8(+) T-cell receptor bias and immundominance in HIV-1 infection

Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available antigen pool derived from a given pathogen. In the case of CD8(+) T-cells, these constrained epitope targeting patterns are linked to human leukocyte antigen (HLA) class-I expressio...

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Publicat a:J Immunol
Autors principals: Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan, Koofhethile, Catherine, Gerritsen, Bram, Kesmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D., Ndung'u, Thumbi, Buus, Søren, Price, David A., Goulder, Philip J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433859/
https://ncbi.nlm.nih.gov/pubmed/25911754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400854
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