CD8(+) T-cell receptor bias and immundominance in HIV-1 infection

Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available antigen pool derived from a given pathogen. In the case of CD8(+) T-cells, these constrained epitope targeting patterns are linked to human leukocyte antigen (HLA) class-I expressio...

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Udgivet i:J Immunol
Main Authors: Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan, Koofhethile, Catherine, Gerritsen, Bram, Kesmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D., Ndung'u, Thumbi, Buus, Søren, Price, David A., Goulder, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433859/
https://ncbi.nlm.nih.gov/pubmed/25911754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400854
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