HLA-A*68:02-restricted Gag-specific CTL responses can drive selection pressure on HIV but are subdominant and ineffective

BACKGROUND: HLA class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of this effect is due to the action of HLA-B and HLA-C alleles. With few exceptions the role of HLA-A molecules in immune control of HIV is unclear. METHODS: We here st...

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Veröffentlicht in:AIDS
Hauptverfasser: Kløverpris, Henrik N., Stryhn, Anette, Harndahl, Mikkel, Carlson, Jonathan M., Leslie, Alasdair J, Chen, Fabian, Riddell, Lynn, Mulenga, Joseph, Walker, Bruce D., Ndung’u, Thumbi, Buus, Søren, Goulder, Philip
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315297/
https://ncbi.nlm.nih.gov/pubmed/23525031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32836146cd
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