HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01

HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia...

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Detalhes bibliográficos
Main Authors: Kløverpris, Henrik N., Stryhn, Anette, Harndahl, Mikkel, Payne, Rebecca, Towers, Greg J., Chen, Fabian, Riddell, Lynn, Walker, Bruce D., Ndung'u, Thumbi, Leslie, Alasdair, Buus, Søren, Goulder, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807415/
https://ncbi.nlm.nih.gov/pubmed/23864640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01122-13
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