Programmed death-1 expression on HIV-1-specific CD8(+) T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

OBJECTIVES: Although CD8(+) T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (P...

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Detalhes bibliográficos
Main Authors: Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David A., Goulder, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166042/
https://ncbi.nlm.nih.gov/pubmed/24906112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000362
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