Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA damage. In this study, we demonstrate that Che-1, a RN...

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Vydáno v:EMBO J
Hlavní autoři: Desantis, Agata, Bruno, Tiziana, Catena, Valeria, De Nicola, Francesca, Goeman, Frauke, Iezzi, Simona, Sorino, Cristina, Ponzoni, Maurilio, Bossi, Gianluca, Federico, Vincenzo, La Rosa, Francesca, Ricciardi, Maria Rosaria, Lesma, Elena, De Meo, Paolo D'Onorio, Castrignanò, Tiziana, Petrucci, Maria Teresa, Pisani, Francesco, Chesi, Marta, Bergsagel, P Leif, Floridi, Aristide, Tonon, Giovanni, Passananti, Claudio, Blandino, Giovanni, Fanciulli, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426481/
https://ncbi.nlm.nih.gov/pubmed/25770584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489920
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