Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA damage. In this study, we demonstrate that Che-1, a RN...

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Publicado en:EMBO J
Autores principales: Desantis, Agata, Bruno, Tiziana, Catena, Valeria, De Nicola, Francesca, Goeman, Frauke, Iezzi, Simona, Sorino, Cristina, Ponzoni, Maurilio, Bossi, Gianluca, Federico, Vincenzo, La Rosa, Francesca, Ricciardi, Maria Rosaria, Lesma, Elena, De Meo, Paolo D'Onorio, Castrignanò, Tiziana, Petrucci, Maria Teresa, Pisani, Francesco, Chesi, Marta, Bergsagel, P Leif, Floridi, Aristide, Tonon, Giovanni, Passananti, Claudio, Blandino, Giovanni, Fanciulli, Maurizio
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426481/
https://ncbi.nlm.nih.gov/pubmed/25770584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489920
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