Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA damage. In this study, we demonstrate that Che-1, a RN...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Desantis, Agata, Bruno, Tiziana, Catena, Valeria, De Nicola, Francesca, Goeman, Frauke, Iezzi, Simona, Sorino, Cristina, Ponzoni, Maurilio, Bossi, Gianluca, Federico, Vincenzo, La Rosa, Francesca, Ricciardi, Maria Rosaria, Lesma, Elena, De Meo, Paolo D'Onorio, Castrignanò, Tiziana, Petrucci, Maria Teresa, Pisani, Francesco, Chesi, Marta, Bergsagel, P Leif, Floridi, Aristide, Tonon, Giovanni, Passananti, Claudio, Blandino, Giovanni, Fanciulli, Maurizio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BlackWell Publishing Ltd 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426481/
https://ncbi.nlm.nih.gov/pubmed/25770584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489920
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