Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization

BACKGROUND: Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse cancer prognosis and leads to resistance to conventional anticancer treatments....

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Bibliografische gegevens
Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Bruno, Tiziana, Valerio, Mariacristina, Casadei, Luca, De Nicola, Francesca, Goeman, Frauke, Pallocca, Matteo, Catena, Valeria, Iezzi, Simona, Sorino, Cristina, Desantis, Agata, Manetti, Cesare, Blandino, Giovanni, Floridi, Aristide, Fanciulli, Maurizio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316229/
https://ncbi.nlm.nih.gov/pubmed/28214471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0497-1
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