Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA damage. In this study, we demonstrate that Che-1, a RN...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Desantis, Agata, Bruno, Tiziana, Catena, Valeria, De Nicola, Francesca, Goeman, Frauke, Iezzi, Simona, Sorino, Cristina, Ponzoni, Maurilio, Bossi, Gianluca, Federico, Vincenzo, La Rosa, Francesca, Ricciardi, Maria Rosaria, Lesma, Elena, De Meo, Paolo D'Onorio, Castrignanò, Tiziana, Petrucci, Maria Teresa, Pisani, Francesco, Chesi, Marta, Bergsagel, P Leif, Floridi, Aristide, Tonon, Giovanni, Passananti, Claudio, Blandino, Giovanni, Fanciulli, Maurizio
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426481/
https://ncbi.nlm.nih.gov/pubmed/25770584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489920
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