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Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain Via Protein Observed (19)F NMR
(19)F NMR of labeled proteins is a sensitive method for characterizing structure, conformational dynamics, higher-order assembly, and ligand binding. Fluorination of aromatic side chains has been suggested as a labeling strategy for small molecule ligand discovery for protein-protein interaction int...
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| 出版年: | Angew Chem Int Ed Engl |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423596/ https://ncbi.nlm.nih.gov/pubmed/25651535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411658 |
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