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Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain Via Protein Observed (19)F NMR
(19)F NMR of labeled proteins is a sensitive method for characterizing structure, conformational dynamics, higher-order assembly, and ligand binding. Fluorination of aromatic side chains has been suggested as a labeling strategy for small molecule ligand discovery for protein-protein interaction int...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423596/ https://ncbi.nlm.nih.gov/pubmed/25651535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411658 |
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