Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment

NMR spectroscopy can be used to quantify the binding affinity between proteins and low-complexity molecules, termed ‘fragments’; this versatile screening approach allows researchers to assess the druggability of new protein targets. Protein-observed (19)F-NMR (PrOF NMR) using (19)F-labeled amino aci...

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Detaylı Bibliyografya
Yayımlandı:Nat Protoc
Asıl Yazarlar: Gee, Clifford T, Arntson, Keith E, Urick, Andrew K, Mishra, Neeraj K, Hawk, Laura M L, Wisniewski, Andrea J, Pomerantz, William C K
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322963/
https://ncbi.nlm.nih.gov/pubmed/27414758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2016.079
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